OVEREXPRESSION OF C-ERBB-2 PROTEIN IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH ADVANCED-STAGE DISEASE

被引：0
|
作者：
FURUI, T [1 ]
IMAI, A [1 ]
MATSUNAMI, K [1 ]
FUSEYA, T [1 ]
TAKAGI, H [1 ]
HORIBE, S [1 ]
TAMAYA, T [1 ]
机构：
[1] GIFU UNIV,SCH MED,DEPT OBSTET & GYNECOL,GIFU 500,JAPAN
来源：
ONCOLOGY REPORTS | 1994年 / 1卷 / 06期
关键词：
ENDOMETRIAL CARCINOMA; C-ERBB-2; PRODUCT; THYROSINE KINASE; AUTOPHOSPHORYLATION; PLASMA MEMBRANE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Expression of the c-erbB-2 product (p185(c-erbB-2)) was examined in plasma membrane isolations from 14 uterine endometrial carcinomas and 3 normal endometrial tissues. Overexpression of p185(c-erbB-2) was found in 8 of 9 endometrial carcinomas of stages III and IV and in none of 5 early stage specimens, when compared with the level in normal endometrial tissues. The expression of p185(c-erbB-2) was independent of histological grade. When the p185(c-erbB-2) immunoprecipitated with anti-p185(c-erbB-2) antibodies was exposed to adenosine triphosphate, enhanced self-phosphorylation occurred more frequently in specimens from the tumors carrying p185(c-erbB-2) overexpression. These findings demonstrated positive correlation between disease spread, p185(c-erbB-2) expression and autophosphorylation of p185(c-erbB-2) in human endometrial carcinoma. The prognostic value of these observations awaits continued study.
引用
收藏
页码：1123 / 1126
页数：4
相关论文
共 50 条
  • [41] CYTOPLASMIC C-ERBB-2 PROTEIN EXPRESSION CORRELATES WITH SURVIVAL IN DUKES B-COLORECTAL CARCINOMA
    KAY, EW
    MULCAHY, H
    WALSH, CB
    LEADER, M
    ODONOGHUE, D
    HISTOPATHOLOGY, 1994, 25 (05) : 455 - 461
  • [42] Correlation of c-erbB-2, EGF and EGFR expression with postoperative survival of patients with advanced carcinoma of the stomach.
    Czyzewska, Jolanta
    Guzinska-Ustymowicz, Katarzyna
    Kemona, Andrzej
    FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, 2009, 47 (04) : 653 - 661
  • [43] OVEREXPRESSION OF C-ERBB-2 PROTEIN IN GASTRIC-CANCER - ITS CORRELATION WITH LONG-TERM SURVIVAL OF PATIENTS
    UCHINO, S
    TSUDA, H
    MARUYAMA, K
    KINOSHITA, T
    SASAKO, M
    SAITO, T
    KOBAYASHI, M
    HIROHASHI, S
    CANCER, 1993, 72 (11) : 3179 - 3184
  • [44] Prognostic significance of p53, PCNA, and c-erbB-2 in endometrial adenocarcinoma
    Heffner, HM
    Freedman, AN
    Asirwatham, JE
    Lele, SB
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 1999, 20 (01) : 8 - 12
  • [45] P53 PROTEIN AND C-ERBB-2 PROTEIN (P185) EXPRESSION IN ENDOMETRIAL ADENOCARCINOMA OF ENDOMETRIOID TYPE - AN IMMUNOHISTOCHEMICAL EXAMINATION ON PARAFFIN SECTIONS
    NIELSEN, AL
    NYHOLM, HCJ
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1994, 102 (01) : 76 - 79
  • [46] Overexpression of c-erbB2 protein correlates with disease-stage and chromosomal gain at the c-erbB2 locus in non-small cell lung cancer
    Kristiansen, G
    Petersen, YYS
    Kaufmann, O
    Schlüns, K
    Dietel, M
    Petersen, I
    EUROPEAN JOURNAL OF CANCER, 2001, 37 (09) : 1089 - 1095
  • [47] c-erbB-2 protein in serum of primary lung cancer patients
    Filiberti, R
    Marroni, P
    Paganuzzi, M
    Izzo, V
    Padovani, P
    Cafferata, M
    Ardizzoni, A
    Neri, M
    Raimondi, L
    Puntoni, R
    CANCER DETECTION AND PREVENTION, 2002, 26 (01): : 64 - 68
  • [48] C-ERBB-2 PROTEIN AND NEUROENDOCRINE EXPRESSION IN INTRADUCTAL CARCINOMAS OF THE BREAST
    LILLENG, R
    HAGMAR, BM
    NESLAND, JM
    MODERN PATHOLOGY, 1992, 5 (01) : 41 - 47
  • [49] The expression of the c-erbB-2 receptor protein in glandular salivary secretions
    Streckfus, CF
    Bigler, L
    Dellinger, T
    Kuhn, M
    Chouinard, N
    Dai, XL
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2004, 33 (10) : 595 - 600
  • [50] DETECTION OF THE LIGAND ACTIVITY OF THE C-ERBB-2 PROTEIN IN CALF SERUM
    SHAN, RJ
    MATSUDA, S
    ICHINO, M
    YAMAMOTO, T
    JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (01): : 15 - 19
12345