OVEREXPRESSION OF C-ERBB-2 PROTEIN IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH ADVANCED-STAGE DISEASE

被引：0
|
作者：
FURUI, T [1 ]
IMAI, A [1 ]
MATSUNAMI, K [1 ]
FUSEYA, T [1 ]
TAKAGI, H [1 ]
HORIBE, S [1 ]
TAMAYA, T [1 ]
机构：
[1] GIFU UNIV,SCH MED,DEPT OBSTET & GYNECOL,GIFU 500,JAPAN
来源：
ONCOLOGY REPORTS | 1994年 / 1卷 / 06期
关键词：
ENDOMETRIAL CARCINOMA; C-ERBB-2; PRODUCT; THYROSINE KINASE; AUTOPHOSPHORYLATION; PLASMA MEMBRANE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Expression of the c-erbB-2 product (p185(c-erbB-2)) was examined in plasma membrane isolations from 14 uterine endometrial carcinomas and 3 normal endometrial tissues. Overexpression of p185(c-erbB-2) was found in 8 of 9 endometrial carcinomas of stages III and IV and in none of 5 early stage specimens, when compared with the level in normal endometrial tissues. The expression of p185(c-erbB-2) was independent of histological grade. When the p185(c-erbB-2) immunoprecipitated with anti-p185(c-erbB-2) antibodies was exposed to adenosine triphosphate, enhanced self-phosphorylation occurred more frequently in specimens from the tumors carrying p185(c-erbB-2) overexpression. These findings demonstrated positive correlation between disease spread, p185(c-erbB-2) expression and autophosphorylation of p185(c-erbB-2) in human endometrial carcinoma. The prognostic value of these observations awaits continued study.
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收藏
页码：1123 / 1126
页数：4
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