EPIDURAL SCOPOLAMINE ADMINISTRATION IN PREVENTING NAUSEA AFTER EPIDURAL MORPHINE

被引：6

作者：

MOSCOVICI, R

PREGO, G

SCHWARTZ, M

STEINFELD, O

机构：

[1] Department of Anesthesiology, Emek Medical Center, Afula

来源：

JOURNAL OF CLINICAL ANESTHESIA | 1995年 / 7卷 / 06期

关键词：

ANESTHESIA; EPIDURAL; MORPHINE; NAUSEA AND VOMITING; POSTOPERATIVE; SCOPOLAMINE;

D O I：

10.1016/0952-8180(95)00056-N

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Study Objective: To determine the effectiveness of epidural scopolamine in preventing nausea and vomiting in patients receiving epidural morphine. Design: Randomized, double-blind study. Setting: Inpatient surgery clinic at a regional general hospital. Patients: 50 patients undergoing major abdominal and lower limb surgery. Interventions: Morphine alone 2.5 to 4 mg was administered via epidural catheter to one group, while the other group received morphine plus scopolamine 0.25 mg via epidural catheter. Measurements and Main Results: Occurrence of nausea and vomiting was recorded during the first postoperative day. Compared with the morphine alone group, the incidence of nausea and vomiting was significantly lower in the morphine plus scopolamine group without difference in the adequacy of analgesia. Conclusion: Epidural scopolamine can be used as an adjunct to epidural morphine in effectively reducing the incidence of postoperative nausea and vomiting.

引用

页码：474 / 476

页数：3

共 16 条

[1]

Jayr, Thomas, Rey, Farhat, Lasser, Bourgain, Postoperative pulmonary complications. Epidural analgesia using bupivacaine and opioids versus parenteral opioids, Anesthesiology, 78, pp. 666-676, (1993)

[2]

Bromage, Camporesi, Durant, Nielsen, Nonrespiratory side effects of epidural morphine, Anesth Analg, 61, pp. 490-495, (1982)

[3]

Cousins, Mather, Intrathecal and epidural administration of opioids, Anesthesiology, 61, pp. 276-310, (1984)

[4]

Clarke, Dundee, Love, Studies of drugs given before anaesthesia. 8. Morphine 10 mg alone and with atropine or hyoscine, Br J Anaesth, 37, pp. 772-778, (1965)

[5]

Stenseth, Sellevold, Breivik, Epidural morphine for postoperative pain: experience with 1,085 patients, Acta Anaesthesiol Scand, 29, pp. 148-156, (1985)

[6]

Uppington, Dunnet, Blogg, Transdermal hyoscine and postoperative nausea and vomiting, Anaesthesia, 41, pp. 16-20, (1986)

[7]

Price, Schmitt, McGuire, Shaw, Trobough, Transdermal scopolamine in the prevention of motion sickness at sea, Clin Pharmacol Ther, 29, pp. 414-449, (1981)

[8]

Weiner, Atropine, scopolamine, and related antimuscarinic drugs, The Pharmacological Basis of Therapeutics, pp. 130-144, (1985)

[9]

Loper, Ready, Dorman, Prophylactic transdermal scopolamine patches reduce nausea in postoperative patients receiving epidural morphine, Anesth Analg, 68, pp. 144-146, (1989)

[10]

Harris, Sevarino, Sinatra, Preble, O'Connor, Silverman, Nausea prophylaxis using transdermal scopolamine in the setting of patient-controlled analgesia, Obstet Gynecol, 78, pp. 673-677, (1991)

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