COMPARISON OF 2 DOSAGES OF PROSTAGLANDIN-F2A ON CANINE UTERINE MOTILITY

被引：5

作者：

WHEATON, LG

BARBEE, DD

机构：

[1] Department of Veterinary Clinical Medicine, Surgery Washington State University Pullman

来源：

THERIOGENOLOGY | 1993年 / 40卷 / 01期

关键词：

PROSTAGLANDIN; OXYTOCIN; INTRAUTERINE PRESSURE; UTERINE MOTILITY;

D O I：

10.1016/0093-691X(93)90345-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of 50 ug/kg prostaglandin F2a (PGF2a) was compared with 250 ug/kg PGF2a on uterine motility in the diestrous female. Microtipped pressure transducers were surgically implanted in the uteri of 6 females at 30 days diestrus and in 6 females at 60 days diestrus. Uterine responses to intravenous PGF2a (5 ug/kg), oxytocin (0.05 USP units/kg), and intramuscular PGF2a (50 ug/kg and 250 ug/kg) were measured in the awake females on Days 1 and 2 after implantation. There was no significant difference in the increase in intrauterine pressure produced by 50 ug/kg of PGF2a compared with 250 ug/kg of PGF2a. The longest duration of the effect occurred when 250 ug/kg of PGF2a were given. Side effects were also documented. Significantly more vomiting occurred when 250 ug/kg PGF2a were given than when 50 ug/kg PGF2a were administered. The only advantage to using a higher dosage of PGF2a appears to be the longer duration of motility.

引用

页码：111 / 120

页数：10