SYNTHESIS, CHARACTERIZATION, AND ANTITUMOR-ACTIVITY OF NEW CHLOROETHYLAMINE PLATINUM COMPLEXES

被引：16

作者：

KHOKHAR, AR

XU, QY

NEWMAN, RA

KIDO, Y

SIDDIK, ZH

机构：

[1] Department of Medical Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1992年 / 45卷 / 03期

关键词：

D O I：

10.1016/0162-0134(92)80046-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and H-1 and Pt-195 NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.

引用

页码：211 / 219

页数：9

共 22 条

[1]

[Anonymous], 1978, INFRARED RAMAN SPECT

[2]

BEHRENS BC, 1987, CANCER RES, V47, P414

[3] CYTO-ACTIVE AMINO-ACID AND PEPTIDE DERIVATIVES .1. SUBSTITUTED PHENYLALANINES [J].