CIRCULATING CONCENTRATIONS OF CALCITONIN GENE-RELATED PEPTIDE (CGRP) IN NORMAL MAN DETERMINED WITH A NEW, HIGHLY SENSITIVE RADIOIMMUNOASSAY

被引：62
|
作者：
SCHIFTER, S
机构：
[1] Department of Clinical Physiology and Nuclear Medicine, KF-4011 Rigshospitalet
来源：
PEPTIDES | 1991年 / 12卷 / 02期
关键词：
CALCITONIN GENE-RELATED PEPTIDE; RADIOIMMUNOASSAY; HUMAN; SERUM CONCENTRATIONS;
D O I：
10.1016/0196-9781(91)90027-M
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A highly sensitive and specific radioimmunoassay for human calcitonin gene-related peptide (CGRP) has been developed and used for determination of serum CGRP levels in 232 normal individuals, 123 females and 109 males, range of age 18 to 79 years. Mean serum concentration was 36.3 pmol/l +/- 6.2 (SD), and serum levels were unrelated to age and sex. The specificity of the assay was confirmed by gel chromatography, followed by HPLC analysis of extracts from normal serum using synthetic alpha- and beta-CGRP as standards.
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页码：365 / 369
页数：5
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