ANTIGEN PRESENTATION BY BRAIN MICROVESSEL SMOOTH-MUSCLE AND ENDOTHELIUM

被引：41

作者：

FABRY, Z ^{[1
]}

WALDSCHMIDT, MM ^{[1
]}

MOORE, SA ^{[1
]}

HART, MN ^{[1
]}

机构：

[1] UNIV IOWA,COLL MED,DEPT PATHOL,DIV NEUROPATHOL,105 MED LABS,IOWA CITY,IA 52242

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 28卷 / 01期

关键词：

Antigen presentation; Class II antigen (Ia); Endothelium; Vascular smooth muscle;

D O I：

10.1016/0165-5728(90)90041-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been previously reported that cultured brain microvessel smooth muscle cells (SM) express major histocompatibility complex (MHC) class II antigen. Here we report that SM is able to present ovalbumin (OVA) antigen to an OVA-specific T cell hybridoma (A2.2E10) and also presents keyhole limpet hemocyanin (KLH) to a KLH-specific T cell clone (HDK-1). Both the class II expression and the antigen-presenting capacity of SM cells is increased by interferonḡg stimulation. Antigen presentation by SM is also MHC restricted as it is blocked by anti-Ia monoclonal antibodies. In contrast to SM, brain endothelium (En) presents whole OVA, digested OVA and KLH poorly, to a much lesser degree than SM, to the same antigen-specific T cells. © 1990.

引用

页码：63 / 71

页数：9

共 35 条

[1] PRIMER REQUIREMENT AND TEMPLATE SPECIFICITY OF DNA POLYMERASE OF RNA TUMOR VIRUSES - (AVIAN MYELOBLASTOSIS VIRUS/MOUSE LEUKEMIA VIRUS/E-COLI DNA POLYMERASE/HOMOPOLYNUCLEOTIDES/OLIGONUCLEOTIDES) [J].

BALTIMORE, D ;

SMOLER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (07) :1507-+

[2]

BENACERRAF B, 1985, AM J PATHOL, V120, P333

[3] RECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON MURINE GLIAL-CELLS [J].

BIRNBAUM, G ;

CLINCHY, B ;

WIDMER, MB .

JOURNAL OF NEUROIMMUNOLOGY, 1986, 12 (03) :225-233

[4] GENETICS OF THE ANTIBODY-RESPONSE TO AN ENDOTHELIAL TRANSPLANTATION ANTIGEN IN THE RAT [J].

BLANKERT, JJ ;

VANES, LA ;

KUNZ, HW ;

CRAMER, DV ;

PAUL, LC .

HUMAN IMMUNOLOGY, 1986, 15 (02) :125-136

[5] AN IMMUNOELECTRON MICROSCOPICAL STUDY OF THE EXPRESSION OF CLASS-II MHC AND A LYMPHOCYTE-T SURFACE MARKER DURING CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS [J].

BUTTER, C ;

HEALEY, DG ;

AGHA, N ;

TURK, JL .

JOURNAL OF NEUROIMMUNOLOGY, 1988, 20 (01) :45-51

[6]

CHAIRWINSKI HM, 1987, J EXP MED, V166, P1229

[7]

DEBAULT LE, 1981, IN VITRO CELL DEV B, V17, P480

[8]

FIERZ W, 1985, J IMMUNOL, V134, P3785

[9] IMMUNE-MEDIATED ENCEPHALITIS - ON THE ROLE OF ANTIGEN-PRESENTING CELLS IN BRAIN-TISSUE [J].

FONTANA, A ;

FREI, K ;

BODMER, S ;

HOFER, E .

IMMUNOLOGICAL REVIEWS, 1987, 100 :185-201

[10] LONG-TERM CULTURE OF TUMOR-SPECIFIC CYTOTOXIC T-CELLS [J].

GILLIS, S ;

SMITH, KA .

NATURE, 1977, 268 (5616) :154-156

← 1 2 3 4 →