ACETYL-L-CARNITINE RESTORES THE DAILY PATTERN OF HYPOTHALAMIC BETA-ENDORPHIN IN RATS EXPOSED TO CONTINUOUS LIGHT

被引：9

作者：

GENAZZANI, AR ^{[1
]}

DERAMUNDO, BM ^{[1
]}

CRISCUOLO, M ^{[1
]}

DEGAETANI, C ^{[1
]}

FICARRA, G ^{[1
]}

GENAZZANI, AD ^{[1
]}

PETRAGLIA, F ^{[1
]}

TRENTINI, GP ^{[1
]}

机构：

[1] UNIV MODENA,SCH MED,INST PATHOL ANAT,I-41100 MODENA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期

关键词：

Acetyl-l-carnitine; Circadian rhythm; Hypothalamus-pituitary-gonadal axis; β-Endorphin;

D O I：

10.1016/0014-2999(90)90431-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the aim of evaluating the effect of acetyl-l-carnitine (ALC) on the daily pattern of hypothalamic β-endorphin (β-EP), we studied the effect of chronic treatment with ALC on hypothalamic β-EP contents after suppression of the dark-phase of the light-dark cycle in female rats. We evaluated the hypothalamic content of β-EP immunoreactivity every 3 h for 24 h in: (1) female rats treated with ALC for 15 days; (2) female rats treated with ALC for 15 days and exposed to continuous light for 24 h. The concentration of β-EP immunoreactivity in tissue extracts was measured by radioimmunoassay. The results demonstrate that concentrations of β-EP immunoreactivity in the medial basal hypothalamus show a circadian rhythm, with β-EP immunoreactivity levels being higher during the night than during the rest of the day. Exposure to continuous light for 24 h abolished the nocturnal increase in hypothalamic β-EP immunoreactivity. Rats treated with ALC showed a daily pattern in the β-EP content of the medial basal hypothalamus similar to that of control rats. These data emphasize the possible role of ALC in restoring or maintaining the endogenous rhythmicity of central β-EP. © 1990.

引用

页码：177 / 180

页数：4