INTERLEUKIN-6 INDUCES HUMAN-IMMUNODEFICIENCY-VIRUS EXPRESSION IN INFECTED MONOCYTIC CELLS ALONE AND IN SYNERGY WITH TUMOR NECROSIS FACTOR-ALPHA BY TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL MECHANISMS

被引：529

作者：

POLI, G ^{[1
]}

BRESSLER, P ^{[1
]}

KINTER, A ^{[1
]}

DUH, E ^{[1
]}

TIMMER, WC ^{[1
]}

RABSON, A ^{[1
]}

JUSTEMENT, JS ^{[1
]}

STANLEY, S ^{[1
]}

FAUCI, AS ^{[1
]}

机构：

[1] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 01期

关键词：

D O I：

10.1084/jem.172.1.151

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunoregulatory cytokine interleukin 6 (1176) directly upregulates production of human immunodeficiency virus (HIV) in acutely as well as in chronically infected cells of monocytic lineage. In addition, 11,6 synergizes with tumor necrosis factor a (TNF-α) in the induction of latent HIV expression. Unlike TNF-α, upregulation ofviral expression induced by IL6 alone does not occur at the transcriptional level and it is not associated with accumulation of HIV RNA. However, when IM and TNF-α synergistically stimulate HIV production, accumulation of HIV RNA and increased transcription are observed, indicating that IM affects HIV expression at multiple (transcriptional and post-transcriptional) levels. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：151 / 158

页数：8

共 43 条

[1] PRODUCTION OF ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED RETROVIRUS IN HUMAN AND NONHUMAN CELLS TRANSFECTED WITH AN INFECTIOUS MOLECULAR CLONE [J].