PHARMACOKINETIC MODEL FOR DIAZEPAM AND ITS MAJOR METABOLITE DESMETHYLDIAZEPAM FOLLOWING DIAZEPAM ADMINISTRATION

被引:21
作者
JACK, ML [1 ]
COLBURN, WA [1 ]
机构
[1] HOFFMANN LA ROCHE INC,DEPT PHARMACOKINET & BIOPHARMACEUT,NUTLEY,NJ 07110
关键词
D O I
10.1002/jps.2600721120
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1318 / 1323
页数:6
相关论文
共 24 条
[1]   CHANGES IN ORAL ABSORPTION CHARACTERISTICS IN MAN OF DIPOTASSIUM CLORAZEPATE AT NORMAL AND ELEVATED GASTRIC PH [J].
ABRUZZO, CW ;
MACASIEB, T ;
WEINFELD, R ;
RIDER, JA ;
KAPLAN, SA .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1977, 5 (04) :377-390
[2]   COMPARATIVE PROTEIN-BINDING OF DIAZEPAM AND DESMETHYLDIAZEPAM [J].
ALLEN, MD ;
GREENBLATT, DJ .
JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 20 (11-1) :639-643
[3]   CONTROLLED-STUDY OF DIAZEPAM IN PSYCHIATRIC OUTPATIENTS [J].
BEERMAN, HM .
AMERICAN JOURNAL OF PSYCHIATRY, 1964, 120 (09) :870-&
[4]   DETERMINATION OF CHLORAZEPATE AND ITS MAJOR METABOLITES IN BLOOD AND URINE BY ELECTRON-CAPTURE GAS-LIQUID-CHROMATOGRAPHY [J].
BROOKS, MA ;
HACKMAN, MR ;
WEINFELD, RE ;
MACASIEB, T .
JOURNAL OF CHROMATOGRAPHY, 1977, 135 (01) :123-131
[5]   STEADY-STATE BIOAVAILABILITY OF 2 CLORAZEPATE DIPOTASSIUM DOSAGE FORMS [J].
CARRIGAN, PJ ;
CHAO, GC ;
BARKER, WM ;
HOFFMAN, DJ ;
CHUN, AHC .
JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 17 (01) :18-28
[6]  
CHUN AHC, 1977, CLIN PHARMACOL THER, V22, P329
[7]  
COTLER S, J PHARM SCI
[8]   EFFECTS AND PLASMA-LEVELS OF N-DESMETHYLDIAZEPAM AFTER ORAL-ADMINISTRATION IN NORMAL VOLUNTEERS [J].
DASBERG, HH .
PSYCHOPHARMACOLOGIA, 1975, 43 (02) :191-198
[9]  
De Silva J A, 1970, Anal Chem, V42, P1725, DOI 10.1021/ac50160a040
[10]   DIAZEPAM, A NEW TRANQUILIZER [J].
DIFRANCESCO, A .
AMERICAN JOURNAL OF PSYCHIATRY, 1963, 119 (10) :989-&