CD40 LIGAND CD40 DEFICIENCY

被引：20

作者：

CASTIGLI, E ^{[1
]}

FULEIHAN, R ^{[1
]}

RAMESH, N ^{[1
]}

TSITSIKOV, E ^{[1
]}

TSYTSYKOVA, A ^{[1
]}

GEHA, RS ^{[1
]}

机构：

[1] CHILDRENS HOSP,DIV IMMUNOL,BOSTON,MA 02115

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

CD40; LIGAND; ISOTYPE SWITCHING; HIGMX-1; KNOCKOUT;

D O I：

10.1159/000236923

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond normally to T-independent antigens.

引用

页码：37 / 39

页数：3

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