THAPSIGARGIN BLOCKS LONG-TERM POTENTIATION INDUCED BY WEAK, BUT NOT STRONG TETANISATION IN RAT HIPPOCAMPAL CA1 NEURONS

被引：54
作者：
BEHNISCH, T
REYMANN, KG
机构：
[1] Federal Institute for Neurobiology, Department of Neurophysiology, D-39008 Magdeburg
来源：
NEUROSCIENCE LETTERS | 1995年 / 192卷 / 03期
关键词：
HIPPOCAMPUS; CA1; LONG-TERM POTENTIATION; INOSITOL 1,4,5-TRISPHOSPHATE; INTERNAL CALCIUM RELEASE; THAPSIGARGIN; RECURRENT INHIBITION;
D O I：
10.1016/0304-3940(95)11641-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To elucidate the role of calcium release from internal stores during different paradigms of tetanisation in long-term potentiation (LTP), we have investigated the effects of thapsigargin on the elevation of the excitatory postsynaptic field potential (fEPSP) and the population spike (PS) after tetanisation. We found no effect on the duration of fEPSP potentiation if thapsigargin was perfused before strong (triple) tetanisation. However, the potentiation was reduced significantly from control experiments if thapsigargin was applied before weak (single) tetanisation. Surprisingly, we did not find any reduction of PS potentiation, which could be due to changes in the recurrent inhibition. We conclude that the involvement of internal calcium release in the mechanisms of LTP induction will be reduced if multiple tetanisation is used.
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收藏
页码：185 / 188
页数：4
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