PROSTACYCLIN (PGI2) PROTECTS RAT CORTICAL-NEURONS IN CULTURE AGAINST HYPOXIA REOXYGENATION AND GLUTAMATE-INDUCED INJURY

被引：43
作者：
CAZEVIEILLE, C [1 ]
MULLER, A [1 ]
BONNE, C [1 ]
机构：
[1] UNIV MONTPELLIER 1, FAC PHARM, PHYSIOL CELLULAIRE LAB, 15 AVE CHARLES FLAHAULT, F-34060 MONTPELLIER, FRANCE
来源：
NEUROSCIENCE LETTERS | 1993年 / 160卷 / 01期
关键词：
PROSTACYCLIN; PGI(2); ISCHEMIA; GLUTAMATE; EXCITOTOXICITY; NEURON CULTURE; HYPOXIA REOXYGENATION;
D O I：
10.1016/0304-3940(93)90924-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Arachidonic acid and its metabolites are released in brain extracellular fluids as a result of ischemia and may participate in either damaging or protecting neural tissues. This study investigates the neuroprotective effect of prostacyclin (PGI2) on hypoxia (5 h)/reoxygenation (3 h) and on the excitotoxic neurotransmitter, glutamate (10 muM), in rat cortical neuron cultures. At muM concentrations, PGI2 inhibits lactate dehydrogenase release, a cell-injury marker. These results, showing a direct cytoprotective effect of PGI2 on brain cells, reinforce its beneficial properties on vessels and circulating cells in cerebral ischemia.
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页码：106 / 108
页数：3
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