A VASCULAR SMOOTH MUSCLES NITRIC-OXIDE RELAXATION BY A MECHANISM DISTINCT OF CALCIUM CHANGES

被引：6
|
作者：
CHABAUD, F [1 ]
DANNA, M [1 ]
BENY, JL [1 ]
机构：
[1] LAB ANAT & PHYSIOL COMPAREES SCI 3,30 QUAI ERNEST ANSERMET,CH-1211 GENEVA 4,SWITZERLAND
来源：
LIFE SCIENCES | 1994年 / 54卷 / 19期
关键词：
CALCIUM; CORONARY ARTERY; SMOOTH MUSCLE; NITRIC OXIDE; VASCULAR RELAXATION;
D O I：
10.1016/0024-3205(94)00600-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Prostaglandin F2alpha contracts coronary arteries smooth muscles under conditions of extra cellular and intracellular calcium depletion. In these conditions, nitrogen-oxide-containing vasodilators or natural EDRF(s) released by the kinins, substance P and bradykinin, from the endothelium relax strips of pig coronary arteries. This indicates that nitric oxide not only needs to lower cytosolic free calcium to relaxes the smooth muscles, but in addition another mechanism, independent of cytosolic calcium changes, is necessary to fully relax strips contracted by Prostaglandin F2alpha.
引用
收藏
页码：1449 / 1458
页数：10
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