MODULATION OF NICOTINIC ACETYLCHOLINE-RECEPTOR FUNCTION IN BOVINE ADRENAL CHROMAFFIN CELLS BY THYMOPENTIN

被引：3
作者：
AFAR, R
TRIFARO, JM
QUIK, M
机构：
[1] MCGILL UNIV,DEPT PHARMACOL & THERAPEUT,3655 DRUMMOND ST,MONTREAL H3G 1Y6,QUEBEC,CANADA
[2] UNIV OTTAWA,DEPT PHARMACOL,OTTAWA K1N 6N5,ONTARIO,CANADA
来源：
BRAIN RESEARCH | 1993年 / 606卷 / 02期
关键词：
THYMOPENTIN; NEURONAL NICOTINIC RECEPTOR; THYMOPOIETIN; NORADRENALINE RELEASE;
D O I：
10.1016/0006-8993(93)91006-E
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Thymopentin is a five amino acid peptide which corresponds to amino acids 32-36 of the thymic polypeptide thymopoietin. Previous work had shown that TP-5 could modulate responsiveness at the muscle-type nicotinic receptor. The present studies show that neuronal nicotinic receptor function, measured as radiolabelled noradrenaline release from bovine adrenal medullary cells, was attenuated by thymopentin. The pentapeptide exhibited specificity for nicotinic receptor evoked release, since thymopentin did not affect potassium-stimulated secretion of [H-3]noradrenaline. It appears, therefore, that thymopentin antagonizes catecholamine release by specifically modulating nicotinic receptor responsiveness.
引用
收藏
页码：346 / 350
页数：5
相关论文
共 37 条
[1]  
AFAR R, 1988, Society for Neuroscience Abstracts, V14, P230
[2]   COOPERATIVITY OF THYMOPOIETIN 32-36 (THE ACTIVE-SITE) AND THYMOPOIETIN 38-45 IN RECEPTOR-BINDING [J].
AUDHYA, T ;
HEAVNER, GA ;
KROON, DJ ;
GOLDSTEIN, G .
REGULATORY PEPTIDES, 1984, 9 (03) :155-164
[3]   CONTRASTING BIOLOGICAL-ACTIVITIES OF THYMOPOIETIN AND SPLENIN, 2 CLOSELY RELATED POLYPEPTIDE PRODUCTS OF THYMUS AND SPLEEN [J].
AUDHYA, T ;
SCHEID, MP ;
GOLDSTEIN, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (09) :2847-2849
[4]  
CHIANG PK, 1991, LIFE SCI, V49, P13
[5]   NICOTINIC ACETYLCHOLINE-RECEPTORS OF NERVE AND MUSCLE - FUNCTIONAL-ASPECTS [J].
COLQUHOUN, D ;
OGDEN, DC ;
MATHIE, A .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1987, 8 (12) :465-472
[6]   PRIMARY STRUCTURE OF AN AGONIST BINDING SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR FROM BOVINE ADRENAL CHROMAFFIN CELLS [J].
CRIADO, M ;
ALAMO, L ;
NAVARRO, A .
NEUROCHEMICAL RESEARCH, 1992, 17 (03) :281-287
[7]   PHARMACOLOGICAL AND FUNCTIONAL DIVERSITY OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS [J].
DENERIS, ES ;
CONNOLLY, J ;
ROGERS, SW ;
DUVOISIN, R .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (01) :34-40
[8]   EFFECT OF THE TP5 ANALOG OF THYMOPOIETIN ON THE REJECTION OF MALE SKIN BY AGED AND THYMECTOMIZED FEMALE MICE [J].
GOLDBERG, EH ;
GOLDSTEIN, G ;
BOYSE, EA ;
SCHEID, MP .
IMMUNOGENETICS, 1981, 13 (03) :201-204
[9]   CONTRASTING EFFECTS OF THYMOPENTIN AND SPLENOPENTIN ON THE CAPACITY OF FEMALE MICE TO REJECT SYNGENEIC MALE SKIN [J].
GOLDBERG, EH ;
GOLDSTEIN, G ;
HARMAN, DB ;
BOYSE, EA .
TRANSPLANTATION, 1984, 38 (01) :52-55
[10]   SYNTHETIC PENTAPEPTIDE WITH BIOLOGICAL-ACTIVITY CHARACTERISTIC OF THE THYMIC HORMONE THYMOPOIETIN [J].
GOLDSTEIN, G ;
SCHEID, MP ;
BOYSE, EA ;
SCHLESINGER, DH ;
VANWAUWE, J .
SCIENCE, 1979, 204 (4399) :1309-1310
1234