EFFECTS OF ANTIHYPERTENSIVE FACTOR FROM ERYTHROCYTE OF SPONTANEOUSLY HYPERTENSIVE RATS ON THE BLOOD-PRESSURE AND CA-2+ INFLUX OF ARTERIAL SMOOTH-MUSCLE IN RATS

被引：0
|
作者：
WEN, YY
CHEN, MQ
JIA, HP
WU, GY
ZHOU, LP
LU, T
ZHANG, SF
机构：
来源：
CHINESE MEDICAL JOURNAL | 1991年 / 104卷 / 05期
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of a partially purified antihypertensive factor (AHF) from erythrocytes of spontaneously hypertensive rats (SHR) on the blood pressure (BP) and Ca2+ influx of vascular smooth muscle (VSM) in rats were studied. The results indicated that AHF could produce a marked prolonged depressor effect and significantly inhibit the Ca2+ influx dose-dependently on both SHR and renal hypertensive rat (RHR) either in acute or in chronic experiments, but not on normotensive rats. It suggested that the inhibition of Ca2+ influx might be one of the important mechanisms for AHF as an endogenous depressor substance.
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页码：376 / 380
页数：5
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