ANALYSIS OF A POSITIVE FEEDBACK MECHANISM IN THE ANTI-SM AUTOANTIBODY RESPONSE OF MRL/MPJ-LPR/LPR MICE

被引：11
|
作者：
STOCKS, MR [1 ]
WILLIAMS, DG [1 ]
MAINI, RN [1 ]
机构：
[1] KENNEDY INST,6 BUTE GARDENS,HAMMERSMITH,LONDON W6 7DW,ENGLAND
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 02期
关键词：
D O I：
10.1002/eji.1830210205
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mechanism of induction of anti-Sm antibodies by passive transfer of anti-Sm mAb in MRL/lpr mice was investigated. No idiotypic relationship was detected between the inducing monoclonal antibody KSm2 and either the induced circulating anti-Sm antibodies or the products of anti-Sm-producing hybridomas derived from spleen cell fusion of treated mice. Treatment of mice with ribonucleoprotein Sm antigen, alone or as an immune complex, induced anti-Sm and anti-ribonucleoprotein antibodies similarly to treatment with KSm2. This suggests that autoantigen contributes to the development of the anti-Sm reponse in MRL mice.
引用
收藏
页码：267 / 272
页数：6
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