ANALYSIS OF A POSITIVE FEEDBACK MECHANISM IN THE ANTI-SM AUTOANTIBODY RESPONSE OF MRL/MPJ-LPR/LPR MICE

被引：11
|
作者：
STOCKS, MR [1 ]
WILLIAMS, DG [1 ]
MAINI, RN [1 ]
机构：
[1] KENNEDY INST,6 BUTE GARDENS,HAMMERSMITH,LONDON W6 7DW,ENGLAND
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 02期
关键词：
D O I：
10.1002/eji.1830210205
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mechanism of induction of anti-Sm antibodies by passive transfer of anti-Sm mAb in MRL/lpr mice was investigated. No idiotypic relationship was detected between the inducing monoclonal antibody KSm2 and either the induced circulating anti-Sm antibodies or the products of anti-Sm-producing hybridomas derived from spleen cell fusion of treated mice. Treatment of mice with ribonucleoprotein Sm antigen, alone or as an immune complex, induced anti-Sm and anti-ribonucleoprotein antibodies similarly to treatment with KSm2. This suggests that autoantigen contributes to the development of the anti-Sm reponse in MRL mice.
引用
收藏
页码：267 / 272
页数：6
相关论文
共 50 条
  • [1] CD28-deficient MRL/Mpj-lpr/lpr mice
    Diane Marshall
    Arthritis Research & Therapy, 3 (1)
  • [2] T-B COLLABORATION IN THE INVITRO ANTI-SM AUTOANTIBODY RESPONSE OF MRL/MP-LPR/LPR MICE
    SHORES, EW
    EISENBERG, RA
    COHEN, PL
    JOURNAL OF IMMUNOLOGY, 1988, 140 (09): : 2977 - 2982
  • [3] Improved generation of catalytic antibodies by MRL/MPJ-lpr/lpr autoimmune mice
    Takahashi, N
    Kakinuma, H
    Hamada, K
    Shimazaki, K
    Yamasaki, Y
    Matsushita, H
    Nishi, Y
    JOURNAL OF IMMUNOLOGICAL METHODS, 2000, 235 (1-2) : 113 - 120
  • [4] EFFECT OF MACROPHAGE ACTIVATION ON LUPUS NEPHRITIS IN MRL/MPJ-LPR/LPR(MRL/L)MICE
    IZUMINO, K
    FUTAMURA, A
    NAKAGAWA, Y
    ENTANI, C
    TAKATA, M
    INOUE, H
    IIDA, H
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1995, 6 (03): : 870 - 870
  • [5] In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice
    Xu, XL
    Blinder, L
    Shen, JK
    Gong, HH
    Finnegan, A
    Williams, JW
    Chong, ASF
    JOURNAL OF IMMUNOLOGY, 1997, 159 (01): : 167 - 174
  • [6] OVERLAP OF THE ANTI-SM AND ANTI-DNA RESPONSES OF MRL MP-LPR LPR MICE
    BLOOM, DD
    DAVIGNON, JL
    COHEN, PL
    EISENBERG, RA
    CLARKE, SH
    JOURNAL OF IMMUNOLOGY, 1993, 150 (04): : 1579 - 1590
  • [7] STOCHASTIC-CONTROL OF ANTI-SM AUTOANTIBODIES IN MRL/MP-LPR/LPR MICE
    EISENBERG, RA
    CRAVEN, SY
    WARREN, RW
    COHEN, PL
    JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (03): : 691 - 697
  • [8] SEX-HORMONES MODULATE THE RESPONSE OF PULMONARY PERIVASCULAR INFLAMMATION TO CYCLOPHOSPHAMIDE THERAPY IN MRL/MPJ-LPR/LPR MICE
    MCKENZIE, WN
    SUNDERRAJAN, EV
    KAVANAUGH, JL
    BRAUN, SR
    ANSBACHER, L
    WALKER, SE
    AMERICAN JOURNAL OF PATHOLOGY, 1988, 131 (03): : 530 - 538
  • [9] Inhibition of (S)-armepavine from Nelumbo nucifera on autoimmune disease of MRL/MpJ-lpr/lpr mice
    Liu, CP
    Tsai, WJ
    Shen, CC
    Lin, YL
    Liao, JF
    Chen, CF
    Kuo, YC
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 531 (1-3) : 270 - 279
  • [10] ENCEPHALITOZOON-CUNICULI INFECTION IN MRL/MPJ-LPR (LYMPHOPROLIFERATION) MICE
    LIU, JJ
    SHADDUCK, JA
    LABORATORY ANIMAL SCIENCE, 1988, 38 (06): : 685 - 688
12345