DECREASED EXPRESSION OF COMPLEMENT RECEPTOR TYPE-2 (CR-2) ON NEOPLASTIC B-CELLS OF CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：0

作者：

TOOZE, JA

BEVAN, DH

机构：

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1991年 / 83卷 / 03期

关键词：

CR2(CD21); B-CLL; FLOW CYTOMETRY;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neoplastic cells from 49 patients with B cell chronic lymphocytic leukaemia (B-CLL) were studied and compared with normal peripheral and tonsillar B cells using CD21 monoclonal antibodies. Membrane expression of CR2 was quantified by calibrated flow cytometry and by binding analysis with radiolabelled antibody. Both assays indicate that B-CLL cells express only 30% of the CR2 found on normal B cells. These findings are further evidence of the aberrant phenotype of B-CLL cells.

引用

页码：423 / 429

页数：7