Circulating tumour cells in breast cancer

被引：15
作者：
Krawczyk, Natalia [1 ]
Banys, Malgorzata [1 ]
Hartkopf, Andreas [2 ]
Hagenbeck, Carsten [1 ]
Melcher, Carola [1 ]
Fehm, Tanja [1 ]
机构：
[1] Univ Duesseldorf, Dept Obstet & Gynecol, Moorenstr 5, D-40225 Dusseldorf, Germany
[2] Univ Tubingen, Dept Obstet & Gynecol, D-72076 Tubingen, Germany
来源：
ECANCERMEDICALSCIENCE | 2013年 / 7卷
关键词：
breast cancer; disseminated tumour cell; circulating tumour cell; prognosis; biomarkers;
D O I：
10.3332/ecancer.2013.352
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies.
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页数：12
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