DISTRIBUTION OF MESSENGER-RNA ENCODING THE INWARDLY RECTIFYING K+ CHANNEL, BIR1 IN RAT-TISSUES

被引：21

作者：

DIXON, AK

GUBITZ, AK

ASHFORD, MLJ

RICHARDSON, PJ

FREEMAN, TC

机构：

[1] SANGER CTR,HUMAN GENET GRP,HINXTON CB10 1RQ,CAMBS,ENGLAND

[2] UNIV CAMBRIDGE,DEPT PHARMACOL,CAMBRIDGE CB2 1QJ,ENGLAND

[3] UNIV ABERDEEN,MARISCHAL COLL,DEPT BIOMED SCI,ABERDEEN AB9 1AS,SCOTLAND

来源：

FEBS LETTERS | 1995年 / 374卷 / 01期

基金：

英国惠康基金;

关键词：

INWARD RECTIFIER; BIR1; RCK(ATP); GIRK1; POTASSIUM CHANNEL; MESSENGER-RNA; HYBRIDIZATION; IN SITU;

D O I：

10.1016/0014-5793(95)01091-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distribution of mRNA encoding the inwardly rectifying K+ channel, BIR1 [1] was investigated in rat tissues, and a comparison made with the expression of related genes rcK(ATP) and GIRK1 using the reverse transcription-polymerase chain reaction (RT-PCR). This showed BIR1 to be expressed in all areas of the brain examined, in the eye but not in any other peripheral tissue. This pattern was distinct from rcK(ATP) and GIRK1. Additional in situ hybridisation studies of the central expression of BIR1 demonstrated high levels of BIR1 mRNA in the hippocampus, dentate gyrus, taenia tecta and cerebellum and at lower levels in the cortex, habenular nucleus, olfactory bulb, primary olfactory cortex, thalamus, pontine nucleus and amygdaloid nucleus.

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页码：135 / 140

页数：6

相关论文

共 18 条

[1] CLONING OF THE BETA-CELL HIGH-AFFINITY SULFONYLUREA RECEPTOR - A REGULATOR OF INSULIN-SECRETION [J].

AGUILARBRYAN, L ;

NICHOLS, CG ;

WECHSLER, SW ;

CLEMENT, JP ;

BOYD, AE ;

GONZALEZ, G ;

HERRERASOSA, H ;

NGUY, K ;

BRYAN, J ;

NELSON, DA .

SCIENCE, 1995, 268 (5209) :423-426

[2] RETRACTED: CLONING AND FUNCTIONAL EXPRESSION OF A RAT-HEART K-ATP CHANNEL (RETRACTED ARTICLE. SEE VOL 378, PG 792, 1995) [J].

ASHFORD, MLJ ;

BOND, CT ;

BLAIR, TA ;

ADELMAN, JP .

NATURE, 1994, 370 (6489) :456-459

[3] CLONING AND FUNCTIONAL EXPRESSION OF THE CDNA-ENCODING AN INWARDLY-RECTIFYING POTASSIUM CHANNEL EXPRESSED IN PANCREATIC BETA-CELLS AND IN THE BRAIN [J].

BOND, CT ;

AMMALA, C ;

ASHFIELD, R ;

BLAIR, TA ;

GRIBBLE, F ;

KHAN, RN ;

LEE, K ;

PROKS, P ;

ROWE, ICM ;

SAKURA, H ;

ASHFORD, MJ ;

ADELMAN, JP ;

ASHCROFT, FM .

FEBS LETTERS, 1995, 367 (01) :61-66

[4]

CHARANDRASENA G, 1992, CELL MOL BIOL, V38, P243

[5] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[6] ATRIAL G-PROTEIN-ACTIVATED K+-CHANNEL - EXPRESSION CLONING AND MOLECULAR-PROPERTIES [J].

DASCAL, N ;

SCHREIBMAYER, W ;

LIM, NF ;

WANG, WZ ;

CHAVKIN, C ;

DIMAGNO, L ;

LABARCA, C ;

KIEFFER, BL ;

GAVERIAUXRUFF, C ;

TROLLINGER, D ;

LESTER, HA ;

DAVIDSON, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10235-10239

[7] THE INWARD RECTIFIER POTASSIUM CHANNEL FAMILY [J].

DOUPNIK, CA ;

DAVIDSON, N ;

LESTER, HA .

CURRENT OPINION IN NEUROBIOLOGY, 1995, 5 (03) :268-277

[8]

DUNNE MJ, 1992, POTASSIUM CHANNEL MO, P110

[9]

EDWARDS G, 1993, ANNU REV PHARMACOL, V33, P597, DOI 10.1146/annurev.pharmtox.33.1.597

[10] CLONING AND FUNCTIONAL-CHARACTERIZATION OF A NOVEL ATP-SENSITIVE POTASSIUM CHANNEL UBIQUITOUSLY EXPRESSED IN RAT-TISSUES, INCLUDING PANCREATIC-ISLETS, PITUITARY, SKELETAL-MUSCLE, AND HEART [J].

INAGAKI, N ;

TSUURA, Y ;

NAMBA, N ;

MASUDA, K ;

GONOI, T ;

HORIE, M ;

SEINO, Y ;

MIZUTA, M ;

SEINO, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) :5691-5694