CONTRASTING DISTRIBUTIONS OF PATCHED AND HEDGEHOG PROTEINS IN THE DROSOPHILA-EMBRYO

被引：110
作者：
TAYLOR, AM
NAKANO, Y
MOHLER, J
INGHAM, PW
机构：
[1] ICRF,DEPT ZOOL,DEV BIOL UNIT,S PARKS RD,OXFORD OX1 3PS,ENGLAND
[2] COLUMBIA UNIV BARNARD COLL,DEPT BIOL SCI,NEW YORK,NY 10027
来源：
MECHANISMS OF DEVELOPMENT | 1993年 / 42卷 / 1-2期
关键词：
DROSOPHILA; SEGMENT POLARITY GENE; CELL INTERACTION; PATCHED; HEDGEHOG;
D O I：
10.1016/0925-4773(93)90101-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The segment polarity genes patched (ptc) and hedgehog (hh) are thought to encode a receptor and signal molecule respectively, components of a signal transduction pathway that regulates the transcription of the wingless gene in the Drosophila embryo. Here we describe the production of antibodies specific for the products of these two genes and the patterns of protein distribution that they reveal in the developing embryo. The results are consistent with the hh protein being secreted by cells in which it is expressed and support a role for ptc in the reception of the putative hh encoded signal.
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页码：89 / 96
页数：8
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