Exploring consumer exposure pathways and patterns of use for chemicals in the environment

被引：91

作者：

Dionisio, Kathie L. ^{[1
]}

Frame, Alicia M. ^{[2
]}

Goldsmith, Michael-Rock ^{[1
]}

Wambaugh, John F. ^{[2
]}

Liddell, Alan ^{[3
]}

Cathey, Tommy ^{[4
]}

Smith, Doris ^{[2
]}

Vail, James ^{[2
]}

Ernstoff, Alexi S. ^{[5
]}

Fantke, Peter ^{[5
]}

Jolliet, Olivier ^{[6
]}

Judson, Richard S. ^{[2
]}

机构：

[1] US Environm Protect Agcy, Natl Exposure Res Lab, 109 TW Alexander Dr,MC E205-02, Res Triangle Pk, NC 27709 USA

[2] US Environm Protect Agcy, Natl Ctr Computat Toxicol, MC B205-01, Res Triangle Pk, NC 27709 USA

[3] North Carolina State Univ, Dept Math, Raleigh, NC 27695 USA

[4] Lockheed Martin, Res Triangle Pk, NC USA

[5] Tech Univ Denmark, Dept Engn Management, Quantitat Sustainabil Assessment, DK-2800 Lyngby, Denmark

[6] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

来源：

TOXICOLOGY REPORTS | 2015年 / 2卷

关键词：

Chemical exposure; Human exposure; High throughput; Exposure prioritization; Use category;

D O I：

10.1016/j.toxrep.2014.12.009

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Humans are exposed to thousands of chemicals in the workplace, home, and via air, water, food, and soil. A major challenge in estimating chemical exposures is to understand which chemicals are present in these media and microenvironments. Here we describe the Chemical/Product Categories Database (CPCat), a new, publically available (http://actor.epa.gov/cpcat) database of information on chemicals mapped to "use categories" describing the usage or function of the chemical. CPCat was created by combining multiple and diverse sources of data on consumer-and industrial-process based chemical uses from regulatory agencies, manufacturers, and retailers in various countries. The database uses a controlled vocabulary of 833 terms and a novel nomenclature to capture and streamline descriptors of chemical use for 43,596 chemicals from the various sources. Examples of potential applications of CPCat are provided, including identifying chemicals to which children may be exposed and to support prioritization of chemicals for toxicity screening. CPCat is expected to be a valuable resource for regulators, risk assessors, and exposure scientists to identify potential sources of human exposures and exposure pathways, particularly for use in high-throughput chemical exposure assessment. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license

引用

页码：228 / 237

页数：10

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