HISTAMINE-RELEASE INDUCED BY GLUCOSE (MANNOSE)-SPECIFIC LECTINS ISOLATED FROM BRAZILIAN BEANS - COMPARISON WITH CONCANAVALIN-A

被引：50

作者：

GOMES, JC ^{[1
]}

FERREIRA, RR ^{[1
]}

CAVADA, BS ^{[1
]}

MOREIRA, RA ^{[1
]}

OLIVEIRA, JTA ^{[1
]}

机构：

[1] FED UNIV CEARA,DEPT BIOCHEM & MOLEC BIOL,FORTALEZA,CEARA,BRAZIL

来源：

AGENTS AND ACTIONS | 1994年 / 41卷 / 3-4期

关键词：

HISTAMINE RELEASE; LECTINS; MAST CELLS;

D O I：

10.1007/BF02001905

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The histamine releasing properties of glucose (mannose)-specific lectins isolated from Brazilian beans was examined. The Canavalia brasiliensis, Dioclea rostrata, and Dioclea virgata lectins induced histamine release in rat peritoneal mast cells similar to concanavalin A. Less potency and efficacy was observed for Canavalia maritima, Dioclea guianensis, and Dioclea violacea while very low activities were seen for the lectins from Dioclea grandiflora, Canavalia bonariensis, and Cratylia floribunda. The histamine releasing effect was quenched by higher doses of D. virgata lectin similar to what was reported for concanavalin A. This effect was abrogated by increasing the concentration of calcium in the incubating medium. As these above proteins have sites that bind calcium, higher doses of the lectins might withdraw the calcium which is essential for the mast cell secretion.

引用

页码：132 / 135

页数：4

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