CHARACTERIZATION OF 2 MARKER CHROMOSOMES IN A PATIENT WITH ACUTE NONLYMPHOCYTIC LEUKEMIA BY 2-COLOR FLUORESCENCE IN-SITU HYBRIDIZATION

被引：9

作者：

TANIWAKI, M ^{[1
]}

SPEICHER, MR ^{[1
]}

LENGAUER, C ^{[1
]}

JAUCH, A ^{[1
]}

POPP, S ^{[1
]}

CREMER, T ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST HUMAN GENET & ANTHROPOL,W-6900 HEIDELBERG,GERMANY

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 70卷 / 02期

关键词：

D O I：

10.1016/0165-4608(93)90175-L

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with acute nonlymphocytic leukemia (ANLL), M5b according to French-American-British (FAB) classification, showed monosomy 16, an extra 1p-, and a 21q+. These derivative chromosomes could not be defined by GTG-banding. For better characterization, we performed two-color fluorescence in situ hybridization (FISH) experiments applying DNA libraries from sorted human chromosomes, chromosome-specific repetitive probes, and a band-specific YAC-clone. With these FISH studies the karyotype could be characterized as 46,XY, + der(1)t(1;21)(p11;?), -16,der(21)t(16;21)(p11.1;q22).

引用

页码：99 / 102

页数：4

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