THE ANTITUMOR-ACTIVITY AND THE STRUCTURE OF BIS(ADENINATO-N9) DIPHENYLTIN(IV)

被引：11

作者：

BARBIERI, R ^{[1
]}

RUISI, G ^{[1
]}

ATASSI, G ^{[1
]}

机构：

[1] INST JULES BORDET,EXPTL CHEMOTHERAPHY & SCREENING LAB,B-1000 BRUSSELS,BELGIUM

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1991年 / 41卷 / 01期

关键词：

D O I：

10.1016/0162-0134(91)85005-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bis(adeninato-N9)diphenyltin(IV) has been selected as a tumor panel compound by the U.S. National Cancer Institute and tested against a number of tumors according to standard protocols. The activity criteria were not passed. The solid state structure of the environment of tin in the complex has been definitely established to be of the tetrahedral type by means of Sn-119 Mossbauer-Zeeman spectroscopy; this configuration has been assumed to be maintained also in aqueous suspensions of the drug, in conditions corresponding to the administration to mice. The occurrence of strong Sn-N bonds, consistently resistant to hydrolytic processes, has been assumed, and correlated to the observed low toxicity of the drug. The extent of the antitumor action corresponds to the standard response to Ph2Sn(IV) moieties.

引用

页码：25 / 30

页数：6

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