MOLECULAR-CLONING OF CDNA FOR SAPECIN-B, AN ANTIBACTERIAL PROTEIN OF SARCOPHAGA, AND ITS DETECTION IN LARVAL BRAIN

被引：10

作者：

LEE, SR

KURATA, S

NATORI, S

机构：

[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo

来源：

FEBS LETTERS | 1995年 / 368卷 / 03期

关键词：

SAPECIN B; CDNA; ANTIBACTERIAL PROTEIN; BRAIN; POTASSIUM CHANNEL INHIBITOR;

D O I：

10.1016/0014-5793(95)00717-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone for sapecin B, an antibacterial protein of Sarcophaga, was isolated. This cDNA encoded a precursor protein of sapecin B consisting of a signal sequence (24 residues), prosegment (30 residues) and mature sapecin B (34 residues). Sapecin B was synthesized almost exclusively in the fat body when the larval body wall was injured, but the brain of naive larvae was also demonstrated to contain a significant amount of sapecin B. These findings suggested that sapecin B is a bifunctional protein.

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收藏

页码：485 / 487

页数：3

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