MOLECULAR-CLONING OF CDNA FOR SAPECIN-B, AN ANTIBACTERIAL PROTEIN OF SARCOPHAGA, AND ITS DETECTION IN LARVAL BRAIN

被引:9
|
作者
LEE, SR
KURATA, S
NATORI, S
机构
[1] Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo
关键词
SAPECIN B; CDNA; ANTIBACTERIAL PROTEIN; BRAIN; POTASSIUM CHANNEL INHIBITOR;
D O I
10.1016/0014-5793(95)00717-N
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A cDNA clone for sapecin B, an antibacterial protein of Sarcophaga, was isolated. This cDNA encoded a precursor protein of sapecin B consisting of a signal sequence (24 residues), prosegment (30 residues) and mature sapecin B (34 residues). Sapecin B was synthesized almost exclusively in the fat body when the larval body wall was injured, but the brain of naive larvae was also demonstrated to contain a significant amount of sapecin B. These findings suggested that sapecin B is a bifunctional protein.
引用
收藏
页码:485 / 487
页数:3
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