First-and Second-Trimester Reference Intervals for Thyroid Hormones during Pregnancy in "Rhea" Mother-Child Cohort, Crete, Greece

被引：28

作者：

Karakosta, Polyxeni ^{[1
,2
]}

Chatzi, Leda ^{[1
]}

Bagkeris, Emmanouil ^{[1
]}

Daraki, Vasiliki ^{[3
]}

Alegakis, Dimitris ^{[1
]}

Castanas, Elias ^{[2
]}

Kogevinas, Manolis ^{[4
,5
]}

Kampa, Marilena ^{[2
]}

机构：

[1] Univ Crete, Fac Med, Dept Social Med, POB 2208, Iraklion GR-71003, Greece

[2] Univ Crete, Fac Med, Dept Expt Endocrinol, Iraklion GR-71003, Greece

[3] Univ Crete, Fac Med, Dept Endocrinol, Iraklion GR-71003, Greece

[4] Ctr Res Environm Epidemiol CREAL, E-08003 Barcelona, Spain

[5] Natl Sch Publ Hlth, Athens GR-11521, Greece

来源：

JOURNAL OF THYROID RESEARCH | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/490783

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estimation and interpretation of thyroid function tests in pregnant women is of utmost importance for maternal, fetal and neonatal health. Our objective was to calculate laboratory-and geography-specific reference intervals for thyroid hormones during pregnancy in an iodine-sufficient area of the Mediterranean, Crete, Greece. This project was performed in the context of " Rhea" mother-child cohort. Fulfillment of extensive questionnaires and estimation of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and antithyroid antibodies were performed. The reference population was defined using inclusion criteria regarding thyroidal, obstetric, and general medical status of women. Reference interval for TSH was 0.052.53 ae IU/ mL for the first and 0.18-2.73 mu IU/mL for the second trimester. 6,8% and 5,9% of women in the first and second trimester, respectively, had TSH higher than the upper reference limit. These trimester-specific population-based reference ranges are essential in everyday clinical practice for the correct interpretation of thyroid hormone values and accurate classification of thyroid disorders.

引用

页数：12

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