HIGH AND LOW INJECTION VOLUMES IN CE FOR IMPROVED QUANTITATIVE-DETERMINATION OF DRUG-RELATED IMPURITIES

被引：32
作者：
ALTRIA, KD
机构：
[1] Pharmaceutical Analysis, Glaxo Group Research, Ware, SG 12 0DP, Herts., Park Road
来源：
CHROMATOGRAPHIA | 1993年 / 35卷 / 9-12期
关键词：
CAPILLARY ELECTROPHORESIS; HIGH-LOW PROCEDURES; DETECTABILITY AND PRECISION; RANITIDINE;
D O I：
10.1007/BF02267905
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of High-Low CE is shown to offer performance improvements when quantitatively determining related impurity levels in drug substance samples. Specific improvements include increases in both the total number and the total level of impurities detected, improved limits of detection, and improved precision when quantifying individual impurities.
引用
收藏
页码：493 / 496
页数：4
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