Disfiguring Annular Sarcoidosis Improved by Adalimumab

被引:11
作者
Kaiser, C. A. [1 ]
Cozzio, A. [1 ]
Hofbauer, G. F. L. [1 ]
Kamarashev, J. [1 ]
French, L. E. [1 ]
Navarini, A. A. [1 ]
机构
[1] Univ Hosp Zurich, Dept Dermatol, Gloriastr 31, CH-8091 Zurich, Switzerland
关键词
Cutaneous sarcoidosis; Systemic sarcoidosis; Sarcoidosis treatment; Adalimumab; TNF-alpha antagonist;
D O I
10.1159/000328796
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Depending on the location, dermatoses can produce blemishes that severely impair quality of life and require highly effective treatment that is otherwise used for extensive skin involvement. We report the case of a 39-year-old, otherwise healthy male disfigured by an 8 x 7-cm hypopigmented and centrally atrophic annular plaque with erythematous indurated borders in an area of scar tissue on his forehead. Skin biopsies revealed noncaseating granulomas, and hilar involvement was identified, leading to the diagnosis of systemic sarcoidosis stage II with cutaneous involvement. The lesions proved resistant to multiple therapies, but responded within 4 months to adalimumab with regression of the lesion and inflammatory infiltrate. The visual analogue scale of disease activity decreased from 7/10 to 3.5/10, and the Dermatology Life Quality Index from 16/30 to 3/30 points. In conclusion, TNF-alpha inhibition can control inflammation and disfigurement by cutaneous sarcoidosis and restore quality of life.
引用
收藏
页码:103 / 106
页数:4
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