Comparison of Propofol and Desflurane Anesthesia Combined with Remifentanyl in Breast Surgery

Aim: In this study, we aimed to compare the effects of propofol and desfluran anesthesia combined with remifentanil anesthesia on the various systems in short-term breast surgery. Material and Method: A prospective, randomized, controlled study design established for the short-term breast surgery planned, 40, ASA I-II patients aged 18-60 year-old. Group P (n=20) was named for the patients administered remifentanil and propofol and Group D (n=20) was named for the patients administered remifentanil and desflurane. For induction therapy, remifentanil of 1 mu g/kg dosage and Propofol of 2mg/kg dosage was adjusted for Group P and remifentanil of 1 mu g/kg dosage and % 3 end expiratory desflurane was adjusted for Group D. LMA applied for all of the patients. Maintenance treatment of remifentanil infusion with the dose of 0,25 mu g/kg/min were used for both groups and Group P was also administered to 90 mu g/kg/min infusion of Propofol. Tenoksikam with the dose of 20mg was used intravenously for all the patients 10min before the surgery finalized. Data of operation time, total anesthesia time, LMA extubation time, eye opening time, the time achievement of Aldrete score of 9 in postoperative period, VAS results and total remifentanil consumption were recorded. Blood samples were collected for ACTH and Cortizol levels 10min. before induction, 15 min after initial surgical incision and at 15th min of recovery period. Results: Hemodynamic stability maintained for both groups and no hemodynamic response occurred after surgical incisions. Wake-up time and recovery time were decreased in group D. We detected that ACTH and Cortizol levels were decreased in both groups although surgical stress was increased. Discussion: We suggest that desflurane-remifentanil drug combination can be used successfully as an alternative to TIVA for outpatient surgery.