CDNA CLONING OF THE HUMAN MONOCARBOXYLATE TRANSPORTER-1 AND CHROMOSOMAL LOCALIZATION OF THE SLC16A1 LOCUS TO 1P13.2-P12

被引：79
作者：
GARCIA, CK
LI, X
LUNA, J
FRANCKE, U
机构：
[1] STANFORD UNIV,MED CTR,BECKMAN CTR,HOWARD HUGHES MED INST,STANFORD,CA 94305
[2] UNIV TEXAS,SW MED CTR,DEPT MOLEC GENET,DALLAS,TX 75235
[3] STANFORD UNIV,MED CTR,DEPT GENET,STANFORD,CA 94305
[4] STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305
来源：
GENOMICS | 1994年 / 23卷 / 02期
关键词：
D O I：
10.1006/geno.1994.1532
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned cDNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human x rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization. (C) 1994 Academic Press, Inc.
引用
收藏
页码：500 / 503
页数：4
相关论文
共 9 条
[1]   LACTATE TRANSPORTER DEFECT - A NEW DISEASE OF MUSCLE [J].
FISHBEIN, WN .
SCIENCE, 1986, 234 (4781) :1254-1256
[2]   CHROMOSOMAL MAPPING OF GENES INVOLVED IN GROWTH-CONTROL [J].
FRANCKE, U ;
YANGFENG, TL ;
BRISSENDEN, JE ;
ULLRICH, A .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986, 51 :855-866
[3]   DIGITIZED AND DIFFERENTIALLY SHADED HUMAN-CHROMOSOME IDEOGRAMS FOR GENOMIC APPLICATIONS [J].
FRANCKE, U .
CYTOGENETICS AND CELL GENETICS, 1994, 65 (03) :206-218
[4]   THE HUMAN-GENE FOR THE BETA-SUBUNIT OF NERVE GROWTH-FACTOR IS LOCATED ON THE PROXIMAL SHORT ARM OF CHROMOSOME-1 [J].
FRANCKE, U ;
DEMARTINVILLE, B ;
COUSSENS, L ;
ULLRICH, A .
SCIENCE, 1983, 222 (4629) :1248-1251
[5]   MOLECULAR CHARACTERIZATION OF A MEMBRANE TRANSPORTER FOR LACTATE, PYRUVATE, AND OTHER MONOCARBOXYLATES - IMPLICATIONS FOR THE CORI CYCLE [J].
GARCIA, CK ;
GOLDSTEIN, JL ;
PATHAK, RK ;
ANDERSON, RGW ;
BROWN, MS .
CELL, 1994, 76 (05) :865-873
[6]   A GENE FOR STARGARDTS-DISEASE (FUNDUS-FLAVIMACULATUS) MAPS TO THE SHORT ARM OF CHROMOSOME-1 [J].
KAPLAN, J ;
GERBER, S ;
LARGETPIET, D ;
ROZET, JM ;
DOLLFUS, H ;
DUFIER, JL ;
ODENT, S ;
POSTELVINAY, A ;
JANIN, N ;
BRIARD, ML ;
FREZAL, J ;
MUNNICH, A .
NATURE GENETICS, 1993, 5 (03) :308-311
[7]  
KIM CM, 1992, J BIOL CHEM, V267, P23113
[8]   GENE FOR LYMPHOID ENHANCER-BINDING FACTOR-I (LEF1) MAPPED TO HUMAN CHROMOSOME-4 (Q23-Q25) AND MOUSE CHROMOSOME-3 NEAR EGF [J].
MILATOVICH, A ;
TRAVIS, A ;
GROSSCHEDL, R ;
FRANCKE, U .
GENOMICS, 1991, 11 (04) :1040-1048
[9]   TRANSPORT OF LACTATE AND OTHER MONOCARBOXYLATES ACROSS MAMMALIAN PLASMA-MEMBRANES [J].
POOLE, RC ;
HALESTRAP, AP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (04) :C761-C782
1