RELATIONSHIP BETWEEN CALCIUM PERMEABILITY AND RECTIFICATION PROPERTIES OF AMPA RECEPTORS IN CULTURED FAT HIPPOCAMPAL-NEURONS

被引：28
作者：
IINO, M
MOCHIZUKI, S
OZAWA, S
机构：
[1] GUNMA UNIV, SCH MED, DEPT PHYSIOL, MAEBASHI, GUMMA 371, JAPAN
[2] YAMANOUCHI PHARMACEUT CO LTD, INST DRUG DISCOVERY RES, MOLEC MED RES LAB, TSUKUBA, IBARAKI 305, JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期
关键词：
GLUTAMATE RECEPTOR; AMPA SUBTYPE; KAINATE; CA2+ PERMEABILITY; IV RELATION; HIPPOCAMPAL NEURON;
D O I：
10.1016/0304-3940(94)90139-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cultured rat hippocampal neurons were classified into three groups on the basis of the functional properties of their AMPA-subtype glutamate receptors. The type I neuron had AMPA receptors with an outwardly rectifying I-V relation and little permeability to Ca2+ whereas the AMPA receptors in the type II neuron were characterized by marked inward rectification and high Ca2+ permeability. In the third type of neuron, the responses of AMPA receptors exhibited intermediate properties in both I-V relation and Ca2+ permeability. We suggest that these intermediate properties in the third type of neuron reflect the coexistence of Ca2+-permeant and Ca2+-impermeant AMPA receptors.
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页码：14 / 16
页数：3
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