DISEASE-SPECIFIC PATTERNS OF LOCUS-CERULEUS CELL LOSS

被引:439
作者
GERMAN, DC
MANAYE, KF
WHITE, CL
WOODWARD, DJ
MCINTIRE, DD
SMITH, WK
KALARIA, RN
MANN, DMA
机构
[1] UNIV TEXAS, SW MED CTR, DEPT CELL BIOL & NEUROSCI, DALLAS, TX 75235 USA
[2] UNIV MANCHESTER, DEPT PATHOL, MANCHESTER M13 9PL, LANCS, ENGLAND
[3] CASE WESTERN RES SCH MED, DEPT NEUROL, CLEVELAND, OH USA
[4] UNIV TEXAS, SW MED CTR, DEPT PATHOL, NEUROPATHOL LAB, DALLAS, TX 75235 USA
[5] UNIV TEXAS, SW MED CTR, DEPT ACAD COMP SERV, DALLAS, TX 75235 USA
[6] BIOGRAPH INC, DALLAS, TX USA
关键词
D O I
10.1002/ana.410320510
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Computer visualization techniques were used to map and to quantitatively reconstruct the entire locus coeruleus, including the nucleus subcoeruleus, to compare the topographic patterns of cell loss in postmortem brains from patients with Parkinson's disease, Alzheimer's disease, and Down syndrome. There was comparable cell loss in all three diseases (approximately 60%) compared with aged normal subjects, and there was a significant loss of nucleus subcoeruleus cells specifically in patients with Parkinson's disease (63%). There was a significant positive correlation between the magnitude of locus coeruleus cell loss and the duration of Alzheimer's disease, but no such correlation was found for Parkinson's disease. In patients with Parkinson's disease, there was comparable cell loss throughout the rostral-caudal extent of the nucleus; however, in patients with Alzheimer's disease and Down syndrome, the greatest cell loss always occurred within the rostral portion of the nucleus, with a relative sparing of caudal cells. These data are consistent with the hypothesis that cell loss in Parkinson's disease is the result of a pathological process that attacks the catecholaminergic cells of the locus coeruleus and the subcoeruleus in general; in Alzheimer's disease and Down syndrome, however, the pathological process only affects the rostral, cortical-projecting locus coeruleus cells and spares the caudal, noncortical-projecting cells.
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收藏
页码:667 / 676
页数:10
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