TRANSFORMING GROWTH-FACTOR-BETA DECREASES THE IMMUNOGENICITY OF RAT ISLET XENOGRAFTS (RAT TO MOUSE) AND PREVENTS REJECTION IN ASSOCIATION WITH TREATMENT OF THE RECIPIENT WITH A MONOCLONAL-ANTIBODY TO INTERFERON-GAMMA

被引：60

作者：

CAREL, JC ^{[1
]}

SCHREIBER, RD ^{[1
]}

FALQUI, L ^{[1
]}

LACY, PE ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 04期

关键词：

D O I：

10.1073/pnas.87.4.1591

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Culture of rat islets of Langerhans for 1 week at 37°C with recombinant transforming growth factor β prolonged the survival of islet xenografts transplanted into diabetic mouse recipients. Treatment of diabetic recipients with a neutralizing monoclonal antibody to murine interferon γ did not affect the survival of islet xenografts cultured 7 days in control medium. However, treatment of donor islets with transforming growth factor β in combination with treatment of diabetic recipients with interferon γ antibody produced a 75% survival of the islet xenografts at 100 days. Fifty percent of the recipients who had accepted their graft for more than 100 days were immune unresponsive to a transplant of freshly isoalted islets from the same donor strain.

引用

页码：1591 / 1595

页数：5

共 29 条

[1] BANCROFT GJ, 1987, J IMMUNOL, V139, P1104
[2] REQUIREMENT OF ENDOGENOUS INTERFERON-GAMMA PRODUCTION FOR RESOLUTION OF LISTERIA-MONOCYTOGENES INFECTION
BUCHMEIER, NA
SCHREIBER, RD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (21) : 7404 - 7408
[3] INTERCELLULAR-ADHESION MOLECULE-1 IS INDUCED ON ISOLATED ENDOCRINE ISLET CELLS BY CYTOKINES BUT NOT BY REOVIRUS INFECTION
CAMPBELL, IL
CUTRI, A
WILKINSON, D
BOYD, AW
HARRISON, LC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (11) : 4282 - 4286
[4] CZARNIECKI CW, 1988, J IMMUNOL, V140, P4217
[5] DIDLAKE RH, 1988, TRANSPLANTATION, V45, P222
[6] GAMBLE JR, 1988, SCIENCE, V242, P97
[7] CONTINUOUS, CLONAL, INSULIN-SECRETING AND SOMATOSTATIN-SECRETING CELL-LINES ESTABLISHED FROM A TRANSPLANTABLE RAT ISLET CELL TUMOR
GAZDAR, AF
CHICK, WL
OIE, HK
SIMS, HL
KING, DL
WEIR, GC
LAURIS, V
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (06): : 3519 - 3523
[8] JACOB CO, 1989, J IMMUNOL, V142, P1500
[9] INVIVO TREATMENT OF (NZBXNZW)F1 LUPUS-LIKE NEPHRITIS WITH MONOCLONAL-ANTIBODY TO GAMMA-INTERFERON
JACOB, CO
VANDERMEIDE, PH
MCDEVITT, HO
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (03) : 798 - 803
[10] PRODUCTION OF TRANSFORMING GROWTH-FACTOR-BETA BY HUMAN LYMPHOCYTES-T AND ITS POTENTIAL ROLE IN THE REGULATION OF T-CELL GROWTH
KEHRL, JH
WAKEFIELD, LM
ROBERTS, AB
JAKOWLEW, S
ALVAREZMON, M
DERYNCK, R
SPORN, MB
FAUCI, AS
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (05) : 1037 - 1050

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