URAPIDIL INHIBITS 5-HYDROXYTRYPTAMINE INDUCED PLATELET-AGGREGATION AND C-14 5-HYDROXYTRYPTAMINE UPTAKE IN PLATELETS

被引：3
作者：
STORCK, J [1 ]
KIRSTEN, R [1 ]
机构：
[1] UNIV FRANKFURT, INST KLIN PHARMAKOL, THEODOR STERN KAI 7, W-6000 FRANKFURT 70, GERMANY
来源：
CURRENT MEDICAL RESEARCH AND OPINION | 1990年 / 12卷 / 02期
关键词：
5-Hydroxytryptamine; Platelet Aggregation; Urapidil;
D O I：
10.1185/03007999009110475
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of urapidil, an a1-antagonist with additional antihypertensive action via central 5HT1A agonism, was determined on platelet aggregation induced by 5HT and adrenaline. The 5HT uptake in human platelets was determined as well. Urapidil inhibited both the 5HT and adrenaline-induced human platelet aggregation and the 5HT uptake by platelets in vitro. The 5HT-induced aggregation was inhibited with a K1 value of 8.8 μM, the adrenaline-induced aggregation with a K1 value of 21.6 μM, and the 5HT uptake non-competitively witha K11 = 1 1.5 μM and a K12=13 μM. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：86 / 92
页数：7
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