C-MYC AS AN INDUCER OF POLYCYSTIC KIDNEY-DISEASE IN TRANSGENIC MICE

被引：199
作者：
TRUDEL, M
DAGATI, V
COSTANTINI, F
机构：
[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT GENET & DEV,NEW YORK,NY 10032
[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT PATHOL,NEW YORK,NY 10032
来源：
KIDNEY INTERNATIONAL | 1991年 / 39卷 / 04期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/ki.1991.80
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In this study, a genetic model of polycystic kidney disease (PKD) has been produced in transgenic mice bearing the murine c-myc gene driven by the SV40 enhancer and the adult beta-globin promoter. These animals reproducibly develop PKD and die of renal failure. The phenotype appears to result from the overexpression of c-myc in the renal tubular epithelium and consequent abnormal cell proliferation. These transgenic mice represent a genetic model of PKD which bears similarities to human autosomal dominant PKD (ADPKD) with respect to renal morphology, renal functional alterations and dominant transmission. Study of these transgenic mice may offer valuable insights into the pathogenesis of PKD.
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收藏
页码：665 / 671
页数：7
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