TRANSMISSION OF IDIOPATHIC (AUTOIMMUNE) THROMBOCYTOPENIC PURPURA BY LIVER-TRANSPLANTATION

被引：57
作者：
FRIEND, PJ
MCCARTHY, LJ
FILO, RS
LEAPMAN, SB
PESCOVITZ, MD
LUMENG, L
POUND, D
ARNOLD, K
HOFFMAN, R
MCFARLAND, JG
ASTER, RH
机构：
[1] INDIANA UNIV, MED CTR, DEPT SURG, INDIANAPOLIS, IN 46204 USA
[2] INDIANA UNIV, MED CTR, DEPT MED, INDIANAPOLIS, IN 46204 USA
[3] INDIANA UNIV, MED CTR, DEPT PATHOL, INDIANAPOLIS, IN 46204 USA
[4] BLOOD CTR SE WISCONSIN INC, MILWAUKEE, WI USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 1990年 / 323卷 / 12期
关键词：
D O I：
10.1056/NEJM199009203231207
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chronic idiopathic thrombocytopenic purpura is an autoimmune disorder in which the destruction of autologous platelets is mediated by autoantibodies directed against platelet-surface constituents.1 Glycoproteins IIb and IIIa, which exist in the platelet membrane in a 1:1 complex (IIb-IIIa), appear to be the main target molecules for these autoantibodies.2 3 4 The destruction of autologous platelets is thought to result from the ingestion of autoantibody-coated platelets by phagocytic cells in the spleen and other organs.1 The functional state of the reticuloendothelial system may influence the rate of cell destruction in individual patients.5 We recently encountered a patient who had severe, life-threatening thrombocytopenia after. © 1990, Massachusetts Medical Society. All rights reserved.
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页码：807 / 811
页数：5
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