SYNTHESIS AND SCREENING OF SOME NOVEL 1-((5-PHENYL-1,3,4-OXADIAZOL-2-YL) METHYL)-3-((PIPERAZIN-1-YL) METHYL)-1H-INDAZOLE

A series of some novel 2-[5-(substituted phenyl)-[ 1,3,4] oxadiazol containing 1H-indazole moiety were synthesized by using of indazole with mannich base on reaction to give 3-(piperazin-1-yl) methyl)-1H-indazole which is turned into Ethyl 2-(3-piperazin-1-yl) methyl)-1H-indazole-1-yl) acetate. The reaction with hydrazine hydrate in ethanol solvent under reflux. The subsequent treatment of 2-(3-((piperazin-1-yl) methyl)-1H-indazole-1-yl) acetohydrazide, with an appropriate aromatic carboxylic acid in presence of polyphosparic acid under reflux afforded the title compounds. The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H NMR and Mass spectral data analysis. Further the compounds are used to find out their ability towards anti microbial and nematicidal activity.