Chronic Obstructive Pulmonary Disease Is Associated with Altered Neuropsychological Performance in Young Adults

被引：12

作者：

De Carolis, Antonella ^{[1
]}

Giubilei, Franco ^{[1
]}

Caselli, Giulio ^{[1
]}

Casolla, Barbara ^{[1
]}

Cavallari, Michele ^{[1
]}

Vanacore, Nicola ^{[2
]}

Leonori, Rita ^{[3
]}

Scrocchia, Ilaria ^{[3
]}

Fersini, Anna ^{[3
]}

Quercia, Augusto ^{[3
]}

Orzi, Francesco ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[2] Natl Inst Hlth, Natl Ctr Epidemiol Surveillance & Hlth Promot, Rome, Italy

[3] Azienda Unita Sanit Locale, PISLL, Viterbo, Italy

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2011年 / 1卷 / 01期

关键词：

Alzheimer's disease; Chronic hypoxia; Chronic obstructive pulmonary disease; Hypoperfusion; Neuropsychological tests;

D O I：

10.1159/000333079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Subjects with ischemic lesions have an increased risk of dementia. In addition, Alzheimer's disease (AD) and vascular cognitive impairment share many risk factors. These observations suggest that different diseases that cause altered blood perfusion of the brain or hypoxia promote AD neurodegeneration. In this case-control, cross-sectional study, we sought to test the hypothesis that hypoxia facilitates cognitive decline. Methods: We looked for altered neuropsychological performance in subjects with chronic obstructive pulmonary disease (COPD) without apparent cardio- or cerebrovascular diseases or risk factors for atherosclerosis. A selected, homogeneous group of workers from two ceramic factories in a small town of central Italy was enrolled in this study. Results: The COPD patients had a slightly, but significantly worse performance than controls in a number of neuropsychological tests. Conclusion: The findings are consistent with the working hypothesis that chronic hypoxia facilitates cognitive decline. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：402 / 408

页数：7

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