Human Cytokinome: a new challenge for systems biology

被引：27

作者：

Costantini, Susan ^{[1
,2
,3
]}

Castello, Giuseppe ^{[1
]}

Colonna, Giovanni ^{[2
,3
]}

机构：

[1] CROM Oncol Res Ctr Mercogliano Fiorentino Lo Vuol, Via Ammiraglio Bianco, I-83013 Mercogliano, Italy

[2] Univ Naples 2, Dept Biochem & Biophys, I-80138 Naples, Italy

[3] Univ Naples 2, CRISCEB Interdept Res Ctr Computat & Biotechnol S, I-80138 Naples, Italy

来源：

BIOINFORMATION | 2010年 / 5卷 / 04期

关键词：

cytokine; chronic inflammation; cancer; systems biology;

D O I：

10.6026/97320630005166

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cytokines play an important role in the evolution of inflammatory processes. Therefore, they are also key components of the cancer evolution, a disease recognized to depend on chronic inflammation. On the whole, we define cytokinome as the totality of these proteins and their interactions in and around biological cells. Understanding the complex interaction network of cytokines in patients affected from cancers should be very useful both to follow the cancer evolution from its early steps and to define innovative therapeutic strategies by using systems biology approaches.

引用

页码：166 / 167

页数：2