MATERNAL SERUM-FREE ALPHA-HUMAN CHORIONIC-GONADOTROPIN LEVELS IN TWIN PREGNANCIES - IMPLICATIONS FOR SCREENING FOR DOWNS-SYNDROME

被引：19

作者：

WALD, NJ

DENSEM, JW

机构：

[1] Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew's Hospital Medical College, London, EC1M 6BQ, Charterhouse Square

来源：

PRENATAL DIAGNOSIS | 1994年 / 14卷 / 08期

关键词：

MATERNAL SERUM SCREENING; DOWNS SYNDROME; FREE ALPHA-HCG; TWIN PREGNANCY;

D O I：

10.1002/pd.1970140811

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Maternal serum free alpha-human chorionic gonadotrophin (free alpha-hCG) levels were determined in twin and singleton pregnancies at 15-22 weeks of gestation using a set of stored serum samples relating to 200 twin pregnancies and 600 singleton control pregnancies matched for gestational age and duration of storage. Free alpha-hCG values are, on average, 1.66 times greater in twin pregnancies than in singleton pregnancies (95 per cent confidence interval 1.56-1.76). If maternal serum free alpha-hCG is used in screening for Down's syndrome, values in twin pregnancies can be adjusted using this result so that screening can be performed in twin pregnancies as well as in singleton pregnancies.

引用

页码：717 / 719

页数：3

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