FAST-ATOM-BOMBARDMENT IN THE STRUCTURAL IDENTIFICATION OF INTERMEDIATES IN THE HYDROLYTIC DEGRADATION OF POLYPHOSPHAZENES

被引：12
|
作者：
CALICETI, P
VERONESE, FM
MARSILIO, F
LORA, S
SERAGLIA, R
TRALDI, P
机构：
[1] UNIV PADUA,CNR,CTR STUDIO CHIM FARMACO & PROD BIOLOGICAMENTE ATTIVI,I-35100 PADUA,ITALY
[2] CNR,IST FOTOCHIM & RADIAZ ALTA ENERGIA,LEGNANO,ITALY
[3] CNR,AREA RIC,I-35100 PADUA,ITALY
来源：
ORGANIC MASS SPECTROMETRY | 1992年 / 27卷 / 11期
关键词：
D O I：
10.1002/oms.1210271108
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fast atom bombardment mass spectrometry was employed in a study related to the hydrolytic degradation of alanine ethyl ester- and imidazole-substituted polyphosphazenes, to be used as matrices for drug release. Some intermediates were identified and their structural assignment was accomplished by means of mass-analysed ion kinetic energy data. All the detected species show the same phosphazene skeleton, consisting of a P4N3 chain, with an increasing number of alanine ethyl ester substituents, and no evidence was found for the presence of imidazole bound to the polymer backbone.
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页码：1199 / 1202
页数：4
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