RELATIVE BIOAVAILABILITY OF A NEW ORAL FORM OF CYCLOSPORINE-A IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：0
作者：
VANDENBORNE, BEEM
LANDEWE, RBM
THE, HSG
MATTIE, H
BREEDVELD, FC
DIJKMANS, BAC
机构：
[1] WEVER HOSP,HEERLEN,NETHERLANDS
[2] LEIDEN UNIV HOSP,DEPT INFECT DIS,LEIDEN,NETHERLANDS
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 39卷 / 02期
关键词：
PHARMACOKINETICS; CYCLOSPORINE A; RHEUMATOID ARTHRITIS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml(-1) h (mean +/- s.d.) vs 2355 +/- 1128 ng ml(-1) h; P = 0.02, 95% Cl (confidence interval of-the difference: 81 to 955 ng ml(-1) h). C-max values were significantly higher after NEO than after SGC (811 +/- 244 ng ml(-1) vs 495 +/- 291 ng ml(-1), P < 0.0001, 95% Cl of the difference: 209 to 422 ng ml(-1)).
引用
收藏
页码：172 / 175
页数：4
相关论文
共 15 条
[1]   THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].
ARNETT, FC ;
EDWORTHY, SM ;
BLOCH, DA ;
MCSHANE, DJ ;
FRIES, JF ;
COOPER, NS ;
HEALEY, LA ;
KAPLAN, SR ;
LIANG, MH ;
LUTHRA, HS ;
MEDSGER, TA ;
MITCHELL, DM ;
NEUSTADT, DH ;
PINALS, RS ;
SCHALLER, JG ;
SHARP, JT ;
WILDER, RL ;
HUNDER, GG .
ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324
[2]  
BACH JF, 1990, TRANSPLANT P, V3, P1296
[3]  
BLECK JS, 1990, DRUG RES, V40, P62
[4]  
CPMP Working Party on Efficacy of Medicinal Products, 1990, PHARMACOL TOXICOL, V67, P361
[5]   TROUGH LEVELS AND CONCENTRATION-TIME CURVES OF CYCLOSPORINE IN PATIENTS UNDERGOING RENAL-TRANSPLANTATION [J].
FREY, FJ ;
HORBER, FF ;
FREY, BM .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1988, 43 (01) :55-62
[6]  
KEOWN PA, 1982, TRANSPLANT P, V14, P659
[7]   A REVIEW OF ASSAY-METHODS FOR CYCLOSPORINE - CLINICAL IMPLICATIONS [J].
KIVISTO, KT .
CLINICAL PHARMACOKINETICS, 1992, 23 (03) :173-190
[8]   WITHIN-DAY CONSISTENCY IN CYCLOSPORINE PHARMACOKINETICS FROM A MICROEMULSION FORMULATION IN RENAL-TRANSPLANT PATIENTS [J].
KOVARIK, JM ;
MUELLER, EA ;
VANBREE, JB ;
ARNS, W ;
RENNER, E ;
KUTZ, K .
THERAPEUTIC DRUG MONITORING, 1994, 16 (03) :232-237
[9]   REDUCED INTERINDIVIDUAL AND INTRAINDIVIDUAL VARIABILITY IN CYCLOSPORINE PHARMACOKINETICS FROM A MICROEMULSION FORMULATION [J].
KOVARIK, JM ;
MUELLER, EA ;
VANBREE, JB ;
TETZLOFF, W ;
KUTZ, K .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 83 (03) :444-446
[10]  
LANDEWE RBM, 1994, J RHEUMATOL, V21, P1631
12