RELATIVE BIOAVAILABILITY OF A NEW ORAL FORM OF CYCLOSPORINE-A IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：0
|
作者：
VANDENBORNE, BEEM
LANDEWE, RBM
THE, HSG
MATTIE, H
BREEDVELD, FC
DIJKMANS, BAC
机构：
[1] WEVER HOSP,HEERLEN,NETHERLANDS
[2] LEIDEN UNIV HOSP,DEPT INFECT DIS,LEIDEN,NETHERLANDS
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 39卷 / 02期
关键词：
PHARMACOKINETICS; CYCLOSPORINE A; RHEUMATOID ARTHRITIS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The relative bioavailability of cyclosporin A (CsA) from a new microemulsion oral formulation (NEO) and the currently used soft gelatine capsule (SGC) was determined at steady state in 12 patients with rheumatoid arthritis. The AUC(0,12 h) values of cyclosporin A were significantly greater after NEO than SGC (2873 +/- 848 ng ml(-1) h (mean +/- s.d.) vs 2355 +/- 1128 ng ml(-1) h; P = 0.02, 95% Cl (confidence interval of-the difference: 81 to 955 ng ml(-1) h). C-max values were significantly higher after NEO than after SGC (811 +/- 244 ng ml(-1) vs 495 +/- 291 ng ml(-1), P < 0.0001, 95% Cl of the difference: 209 to 422 ng ml(-1)).
引用
收藏
页码：172 / 175
页数：4
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