Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death

被引：2

作者：

Dewson, Grant ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic, Australia

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 01期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Bax; Bak VDAC2; apoptosis; mitochondria;

D O I：

10.4161/23723556.2014.974460

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have revolutionized our understanding of how the crucial apoptosis effectors Bax and Bak target mitochondria to kill cells. We recently reported that an important determinant of the localization, oligomerization, and apoptotic function of Bax is an interaction with either mitochondrial voltage-dependent anion channel 2 (VDAC2) ( in healthy cells) or Bak (in apoptotic cells).(1)

引用

页数：3

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