REGULATION OF GLYCOLYSIS IN SKELETAL-MUSCLE

被引：25

作者：

RAMAIAH, A ^{[1
]}

机构：

[1] ALL INDIA INST MED SCI, NEW DELHI 110016, INDIA

来源：

LIFE SCIENCES | 1976年 / 19卷 / 04期

关键词：

D O I：

10.1016/0024-3205(76)90223-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Four hypotheses to explain the several hundred fold activation of phosphofructokinase and thus glycolysis in muscle during muscular contraction were examined. They are: adenine nucleotide control; an extension of this hypothesis with 5''AMP amplifying the change in glycolytic flux by modifying the phosphofructokinase/fructose 1, 6 diphosphatase cycle; synergistic activation of phosphofructokinase by its various effectors; and Ca2+ translocation and compartmentation of phosphofructokinase in the sarcoplasmic reticulum. Synergism among the effectors of phosphofructokinase is perhaps the major mechanism by which its activity is increased by several hundred fold during muscular contraction, and Ca2+ translocation during muscular contraction can activate 25-30% of total cellular phosphofructokinase that is located in the sarcoplasmic reticulum.

引用

页码：455 / 465

页数：11

共 39 条

[1]

ATKINSON DE, 1967, J BIOL CHEM, V242, P3239

[2] METABOLIC FLUX THROUGH PHOSPHOFRUCTOKINASE AND FRUCTOSE 1,6-DIPHOSPHATASE [J].