Leukocytoclastic Vasculitis after Long-Term Treatment with Sunitinib: A Case Report

被引：5

作者：

Karadimou, Alexandra ^{[1
]}

Migou, Magdalini ^{[1
]}

Economidi, Afroditi ^{[2
]}

Stratigos, Alexandros ^{[2
]}

Kittas, Christos ^{[3
]}

Dimopoulos, Meletios A. ^{[1
]}

Bamias, Aristotle ^{[1
]}

机构：

[1] Univ Athens, Dept Clin Therapeut, Athens, Greece

[2] Univ Athens, Dept Dermatol, Athens, Greece

[3] Univ Athens, Dept Histol, Athens, Greece

来源：

CASE REPORTS IN ONCOLOGY | 2011年 / 4卷 / 02期

关键词：

Renal cell cancer; Sunitinib; Leukocytoclastic vasculitis;

D O I：

10.1159/000331419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report on a 63-year-old woman, previously in good health, who had undergone nephrectomy for clear cell renal cell carcinoma in 2002. Because of systemic relapse with multiple lung metastases in 2006, the patient was treated with sunitinib 50 mg daily on a 4-weeks on-/2-weeks off-schedule. After 3 years of treatment, she developed a purpuric rash on her feet and trunk. Biopsy revealed leukocytoclastic vasculitis. No other organ involvement was diagnosed. She was started on oral prednisone 30 mg daily with rapid resolution of the vasculitic skin lesions. Sunitinib was temporally discontinued and reintroduced at the same dose level. Reappearance of a less serious vasculitis after 2 cycles of re-treatment was resolved in the weeks off-treatment and by reducing the dose of sunitinib along with 5 mg of prednisone daily. One year after the diagnosis, the patient is still on this therapy. Oncology providers should be aware of this rare but potentially serious, possible adverse effect of sunitinib.

引用

页码：385 / 391

页数：7

共 16 条

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