THE EFFECTS OF MM-CREATINE KINASE-DEFICIENCY ON SUSTAINED FORCE PRODUCTION OF MOUSE FAST SKELETAL-MUSCLE

被引：12

作者：

DEHAAN, A ^{[1
]}

KOUDIJS, JCM ^{[1
]}

WEVERS, RA ^{[1
]}

WIERINGA, B ^{[1
]}

机构：

[1] UNIV NIJMEGEN,FAC MED SCI,6500 HB NIJMEGEN,NETHERLANDS

来源：

EXPERIMENTAL PHYSIOLOGY | 1995年 / 80卷 / 03期

关键词：

D O I：

10.1113/expphysiol.1995.sp003863

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Twitch force production was normal in muscles of mice which lack MM-creatine kinase, but the tetanic force:twitch force ratio was lower than in control muscles (3.60 vs. 4.27; P < 0.05). In a series of repeated tetanic contractions the force in the second contraction was already markedly depressed (20-50%), while subsequently only small changes were observed. The effect was greater in exercise that would require a higher metabolic peak flux. The depressed force production was not accompanied by a slowing of relaxation, indicating that enough ATP was present to sustain myofibrillar ATPase and Ca2+-ATPase activity.

引用

页码：491 / 494

页数：4