ACCEPTOR ANALOGS AS POTENTIAL INHIBITORS OF BOVINE BETA-1,4-GALACTOSYL TRANSFERASE

被引：12
作者：
FIELD, RA [1 ]
NEVILLE, DCA [1 ]
SMITH, RW [1 ]
FERGUSON, MAJ [1 ]
机构：
[1] UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期
关键词：
D O I：
10.1016/0960-894X(94)80002-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 4- and B-substituted derivatives of benzyl N-acetyl-beta-(D) under bar-glucosaminide were prepared and assessed as inhibitors of bovine beta-1,4-galactosyl transferase. Of the azido, amino, and acetamido compounds tested, only the 4-amino compound (2) produced significant inhibition of this enzyme.
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页码：391 / 394
页数：4
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